Application of fiber tractography and diffusion tensor imaging to evaluatespinal cord diseases in dogs

The Journal of Veterinary Medical Science

Yujiro ASADA¹  Yasuyoshi KUROIWA¹  Atsushi YAMASHITA¹  Yuko KONISHI²  Mizuki KUSAKA²  Taketoshi ASANUMA²  Hiroyuki SATOH² 

[1] Department of Pathology, Faculty of Medicine,University of Miyazaki, Miyazaki 889-1692, Japan;Laboratory of Veterinary Clinical Radiology, Departmentof Veterinary Sciences, Faculty of Agriculture, University of Miyazaki, Miyazaki889-2192, Japan

关键词: diffusion tensor imaging;    dog;    fiber tractography;    MRI;    spinal cord disease;   

DOI  :  10.1292/jvms.16-0504

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Fiber tractography is a technique capable of depicting the three-dimensional structureand connectivity of nerve fibers using serial magnetic resonance diffusion tensor imaging(DTI). To establish fiber tractography and DTI methods in veterinary clinical medicine, weevaluated fiber tractography and DTI parameters apparent diffusion coefficient (ADC)values and fractional anisotropy (FA) values, in various spinal cord diseases. Spinal cordDTI was examined in 28 dogs with spinal cord diseases. The ADC and FA values were measuredat lesion sites and cranial normal sites on spinal cords, and both values of lesion siteswere compared with normal sites. In thoracolumbar intervertebral disk herniation (IVDH)cases, depending on their neurologic grades, fiber tractography indicated rupture of fibertrajectories, loss of neuronal bundles and disorder of fiber directions. In these cases,the average ADC values at lesion sites significantly decreased compared with normal sites(P=0.016). In the progressive myelomalacia case, the average ADC and FAvalues of hyperintense swollen regions in T2WI decreased compared to both values in otherdisease cases. Finally, in the meningioma case, the continuity of fiber trajectoriesimproved after the administration of an anticancer agent. This study suggests that fibertractography and DTI are useful in the diagnosis and prognosis of veterinary spinal corddiseases.

【 授权许可】

Unknown