Adipose tissue macrophages develop from bone marrow–independent progenitors in Xenopus laevis and mouse

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

Rö¹  Hoang, Anh C.¹  Popp, Manuela¹  , Sarah¹  szer, Tamá²  s³  Noble, Anna³  Strauß⁴  Guille, Matthew⁴  Ampem, Grace⁴ 

[1] Ambystoma Mexicanum Bioregeneration Center, Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Hannover Medical School, Medizinische Hochschule Hannover, Hannover, Germany;EuropeanResource Centre, School of Biological Sciences, University of Portsmouth, Portsmouth, United Kingdom;Institute of Comparative Molecular Endocrinology, University of Ulm, Ulm, Germany

关键词: fat body;    yolk sac Mϕ;    s;    CX3CR1;    neuropeptide FF;   

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

ATMs have a metabolic impact in mammals as they contribute to metabolically harmful AT inflammation. The control of the ATM number may have therapeutic potential; however, information on ATM ontogeny is scarce. Whereas it is thought that ATMs develop from circulating monocytes, various tissue-resident Mϕs are capable of self-renewal and develop from BM-independent progenitors without a monocyte intermediate. Here, we show that amphibian AT contains self-renewing ATMs that populate the AT before the establishment of BM hematopoiesis. Xenopus ATMs develop from progenitors of aVBI. In the mouse, a significant amount of ATM develops from the yolk sac, the mammalian equivalent of aVBI. In summary, this study provides evidence for a prenatal origin of ATMs and shows that the study of amphibian ATMs can enhance the understanding of the role of the prenatal environment in ATM development.

【 授权许可】

CC BY