Acute oral toxicity study of polyherbal formulation AV/KPC/10

International Journal of Biomedical and Advance Research

M M Gatne ; Adarsh Adarsh ; Ravikanth K

关键词: s AV/KPC/10, OECD guidelines, Necropsy;   

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

The current study was designed to study acute oral toxicity study of polyherbal formulation AV/KPC/10 (M/S Ayurvet Limited, Baddi, India) according to OECD guidelines. For new substances it is the recommended stepwise testing approach for developing scientifically sound data on the safety of the substance. Three wistar rats (2 females and 1 male) were used for the study. AV/KPC/10 in single oral dose (2000mg/kg) supplemented to all rats. The parameters like general appearance, behavior, body weight, mortality and necropsy were studied. No changes in general appearance and mortality was observed. AV/KPC/10 was found to be safe at dose of 2000mg/kg.

【 授权许可】

CC BY