Inflammatory properties of antibiotic-treated bacteria

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

Liu, George Y.⁴  Underhill, David M.⁶ 

[1] and;and..Division of Pediatric Infectious Diseases, Cedars‐..Division of Immunology, Department of Biomedical Sciences, Cedars‐Division of Immunology, Department of Biomedical Sciences, Cedars‐F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars‐Sinai Medical Center, Los Angeles, California, USA

关键词: peptidoglycan;    Staphylococcus aureus;    autolysis;    β    ‐;    lactam;   

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Antibiotics have proven to be enormously effective tools in combating infectious diseases. A common roadblock to the effective use of antibiotics is the development of antibiotic resistance. We have recently observed that the very mechanism by which methicillin-resistant Staphylococcus aureus (MRSA) becomes antibiotic resistant causes the organism to be more inflammatory to innate immune cells. In this review, we offer some thoughts on the ways in which antibiotics have been observed to influence immune responses to bacteria.

【 授权许可】

CC BY