Sensitive Electrochemical Determination of Folic Acid Using ex–situ Prepared Bismuth Film Electrodes

Croatica Chemica Acta

Buljac, Maša¹  Bralić, Marija¹  Vladislavić, Nives²  Buzuk, Marijo²  Brinić, Slobodan²  Kožuh, Stjepan³ 

[1] Faculty of Chemistry and Technology, Department of Environmental Chemistry, University of Split, Split, Croatia;Faculty of Chemistry and Technology, Department of General and Inorganic, Chemistry, University of Split, Split, Croatia;Faculty of Metallurgy, University of Zagreb, Sisak, Croatia

关键词: bismuth film;    folic acid;    voltammetry;    electroanalytical;   

DOI  :  10.5562/cca3162

学科分类：化学（综合）

来源: Croatica Chemica Acta

【 摘 要 】

The electrochemical behavior of folic acid (FA), at the electrochemically prepared ex situ bismuth film (BiF) on glassy carbon electrode, clearly indicates electrocatalytic nature of the prepared film toward FA reduction (at –0.55 V). Scanning electron microscopy is used for morphological characterization of the prepared BiF. Accordingly, we establishing an electrochemical procedure based on square wave cathodic stripping voltammetry, preceded by accumulation of FA on the BiF electrode (BiFE). This analytical method is optimized and its analytical performance is presented. This electrode displays a two linear response range: 0.1 to 1.0 μmol L–1 and 1.0–10.0 μmol L–1 with sensitivity of 20.10 μA μmol–1 L and 2.28 μA μmol–1 L, respectively. Developed method was validated in compliance with spectrophotometric method. Excellent recovery and standard deviation obtained with BiFE revealed great analytical potential of the proposed method which was applied for the determination of FA in pharmaceuticals formulation.

【 授权许可】

CC BY