Cerebral malaria among children from central Sudan and intercellular adhesion molecule-1 mutation

International Journal of Medicine and Medical Sciences

Mohammed S. Zaroog¹  Adil Mergani²  Ali Babkier Haboor²  Nase El Din M. A. Elwali²  Ahmed El Tahir³  Bella Awadelseed⁴  El Fatih Hashim⁴  Mohamed Gumma⁵ 

[1] Department of Biochemistry, Applied Medical Science, University of Gezira, Sudan.;Department of Molecular Biology, Institute of Nuclear Medicine, Molecular Biology and Oncology, University of Gezira,Sudan;Faculty of Medicine, King Fahad Medical City, Kingdom of Saudi Arabia.;Faculty of Medicine, University of Sinnar, Sudan;Singa Hospital, Ministry of Health, Sudan.

关键词: ICAM-1;    cerebral malaria;    children;    central Sudan.;   

学科分类：医学（综合）

来源: Academic Journals

【 摘 要 】

The study was carried out to investigate the distribution of cerebral malaria in central region and to identify ICAM-1 alleles and genotypes frequency in Sudanese population in the region. Fifty children with cerebral malaria and 50 age- and sex-matched healthy controls with no history of cerebral malaria were enrolled in the study. The highest incidence of cerebral malaria was found between the ages of 4 – 8 years. From 10 different tribal stocks, 28% of incidents belong to the Johayna tribe in the western region of central Sudan. The incidence of cerebral malaria in this study is influenced by geographical, age, and ethnic factors with no gender variation. From this study four (8%) of study subjects died, 4 (8%) survived with neurological sequel and 42 (84%) were discharged alive and healthy after treatment regimen. The use of allele specific PCR (ASP) for genetic analysis in this study, indicated incidence of the heterozygous form (K29/M29) is 26% in cerebral malaria patients and 12% in the control group, while only one (2%) mutant homozygous (M29/M29) was detected in cerebral malaria patients group. All subjects who carried mutant allele (heterozygous and homozygous mutant) had 3 times susceptibility to cerebral malaria than the other group (P-value= 0.038, Odd Ratio = 2.5; 95% CI 1.011 - 6.181). The incidence of ICAM-1kilifi allele frequency in the study group was 11%, and this may increase the risk for susceptibility to cerebral malaria in Sudanese children inhabiting these regions.

【 授权许可】

Others