Role of myeloid-derived suppressor cells in allogeneic hematopoietic cell transplantation

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

Blazar, Bruce R.¹ 

[1] Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota, USA

关键词: GVHD;    MDSC;    cellular therapy;    inflammation;    immune suppression;   

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Graft-versus-host disease (GVHD) can be a devastating complication for as many as a third of patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HCT). A role for myeloid cells in the amplification of GVHD has been demonstrated; however, less is understood about a potential regulatory role that myeloid cells play or whether such cells may be manipulated and applied therapeutically. Myeloid-derived suppressor cells (MDSCs) are a naturally occurring immune regulatory population that are engaged and expand shortly after many forms of immune distress, including cancer, trauma, and infection. As MDSCs are often associated with chronic disease, inflammation, and even the promotion of tumor growth (regarding angiogenesis/metastasis), they can appear to be predictors of poor outcomes and therefore, vilified; yet, this association doesn’t match with their perceived function of suppressing inflammation. Here, we explore the role of MDSC in GVHD in an attempt to investigate potential synergies that may be promoted, leading to better patient outcomes after allo-HCT.

【 授权许可】

CC BY