Antidiabetic, Hypolipidimic and Antioxidant Activities of Hibiscus Rosa Sinensis Flower Extract in Alloxan Induced Diabetes in Rabbits

International Journal of Biomedical and Advance Research

Mohan Pethe ; Samir Yelwatkar ; Vijay Gujar ; Sushil Varma ; Smita Manchalwar

关键词: s Alloxan induced Diabetes;    Hydroalcoholic extract;    Hibiscus rosa sinensis;    Glibenclamide;    Rabbits;   

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

Aim and Objective: Aim of the present research was to evaluate various biological activities of Hibiscus Rosa Sinensis flower extract in alloxan induced diabetes in rabbits. Materials and Methods: Albino rabbits of either sex weighing between 1.5 to 2.5 kg were chosen for the study and divided into 6 groups of 6 animals each. The hydroalcoholic extract of Hibiscus Rosa Sinensis flowers (HEFHR) was used as test extract. Glibenclamide was administered as drug for comparison. Diabetes was induced by alloxan (150 mg/kg body weight). Group I served as normal control and group II as diabetic control. Group III, IV, V received HEFHR in the doses of 50, 100, 200 mg/kg orally respectively whereas group VI received glibenclamide 5mg/kg body weight for a period of 72 hrs. Results: HEFHR was found to be more effective in antidiabetic activity than glibenclamide, as flower extract produced a gradual fall in blood sugar level in 72 hour whereas glibenclamide has shown sudden fall in blood sugar level within 24 hours which remains constant up to 72 hour. The oral administration of flower extract has significantly improved dyslipidemia by reducing raised level of lipids and it was more efficacious in lipid lowering effect, when compared to glibenclamide. Flower extract of hibiscus was more effective in antioxidative activity than glibenclamide. Conclusion: Significant anitidiabetic effect of flower extract in rabbits may be due to antioxidant properties and significant antidyslipidemic effect protects the cardiac complications especially ischemic heart disease. Hence, it may be a safe and better alternative available over the antidiabetic agents.

【 授权许可】

CC BY