The Pulmonate Limpet Siphonaria lessoni: Pharmacological Study of Norsiphonarienone, a Polipropionate

Pakistan Veterinary Journal

José L Martinez ; Juana Rovirosa ; Claudio Laurido

关键词: Norsiphonarienone;    Pharmacological study;    Rat thoracic aorta;    Siphonaria lessoni;   

学科分类：兽医学

来源: University of Agriculture * Faculty of Veterinary Science

【 摘 要 】

We presented a marine natural product, norsiphonarienone, isolated fromSiphonaria lessoni, a pulmonate limpet of Central Chile. The norsiphonarienone was pharmacologically studied in rat thoracic aorta with endothelium previously contracted with phenylephrine. This technique has been widely used to describe pharmacological characterization and seek for mechanisms of action of natural products and other physiological phenomena. The main characteristics described are pD2 (-log EC50) and maximum effect or maximal contraction (Emax). The results show that norsiphonarienone induced a significant difference in the maximal contraction and also in the pD2 (-log EC50).

【 授权许可】

CC BY-NC