Wnt signaling in granulosa cell tumors of the ovary

Proceedings in Obstetrics and Gynecology

Michael J. Goodheart¹  Brian M. Kilonzo¹  Traci Neff¹  Megan I. Samuelson² 

[1] Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242;Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242

关键词: Granulosa cell tumor;    ovarian neoplasms;    Wnt signaling;   

学科分类：妇产科学

来源: University of Iowa

【 摘 要 】

Granulosa cell tumors (GCT), a malignant type of sex-cord stromal tumor, account for approximately 2-5% of all ovarian malignancies.They are often identified before they have spread beyond the ovary, but advanced disease can be quite challenging to treat.Wnt signaling has been suggested to contribute to the formation of GCT.We hypothesized Wnt signaling was involved in human GCT.

【 授权许可】

Unknown