Cell-autonomous stress responses in innate immunity

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

Blander, J. Magarian⁴ 

[1] ..Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA;..Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA:..Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA;..The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA;Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA

关键词: autophagy;    mTOR;    ER stress/UPR;    mitochondrial stress;    DNA damage response;    stress granules;   

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

The innate immune response of phagocytes to microbes has long been known to depend on the core signaling cascades downstream of pattern recognition receptors (PRRs), which lead to expression and production of inflammatory cytokines that counteract infection and induce adaptive immunity. Cell-autonomous responses have recently emerged as important mechanisms of innate immunity. Either IFN-inducible or constitutive, these processes aim to guarantee cell homeostasis but have also been shown to modulate innate immune response to microbes and production of inflammatory cytokines. Among these constitutive cell-autonomous responses, autophagy is prominent and its role in innate immunity has been well characterized. Other stress responses, such as metabolic stress, the ER stress/unfolded protein response, mitochondrial stress, or the DNA damage response, seem to also be involved in innate immunity, although the precise mechanisms by which they regulate the innate immune response are not yet defined. Of importance, these distinct constitutive cell-autonomous responses appear to be interconnected and can also be modulated by microbes and PRRs, which add further complexity to the interplay between innate immune signaling and cell-autonomous responses in the mediation of an efficient innate immune response.

【 授权许可】

CC BY