Microglia-driven regulation of oligodendrocyte lineage cells, myelination, and remyelination

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: myeloid cells;    innate immune system;    development;    regeneration;   

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Microglia are the resident macrophages of the CNS and members of the innate immune system. As such, they serve important functions in surveillance for indicators of damage and subsequent initiation of an inflammatory response. Although often implicated in neural damage, recent studies have also suggested beneficial roles of activated microglia and inflammation in developmental and regenerative processes in the CNS. These include regulating events leading to the generation and regeneration of myelin, the insulation surrounding nerve fibers which is critical for nerve health and function. This critical review discusses the evidence for the supportive role of microglia in these processes and the cellular and molecular components involved.

【 授权许可】

CC BY