Haemocompatibility Of Non-Functionalized And Plasmachemical Functionalized Detonation Nanodiamond Particles

Archives of Metallurgy and Materials

M. Cicha¹  I. Kotela¹  M. Jedrzejewska-Szczerska²  S. Mitura³  K. Mitura³  P. Ceynowa³  M. Dudek⁴ 

[1] CENTRAL CLINICAL HOSPITAL OF THE MINISTRY OF INTERIOR IN WARSAW, 137 WO?OSKA STR., 02-507 WARSZAWA, POLAND;GDA?SK UNIVERSITY OF TECHNOLOGY, FACULTY OF ELECTRONICS, TELECOMMUNICATIONS AND INFORMATICS, DEPARTMENT OF METROLOGY AND OPTOELECTRONICS, 11/12 GABRIELA NARUTOWICZA STR., 80-233 GDA?SK, POLAND;KOSZALIN UNIVERSITY OF TECHNOLOGY, DEPARTMENT OF BIOMEDICAL ENGINEERING, 2 ?NIADECKICH STR., 75-453 KOSZALIN, POLAND;LODZ UNIVERSITY OF TECHNOLOGY, INSTITUTE OF MATERIALS SCIENCE AND ENGINEERING, 1/15 STEFANOWSKIEGO STR., 90-924 LODZ, POLAND

关键词: Keywords: detonation nanodiamond particles;    modified detonation nanodiamond;    MW PACVD;    haemocompatibility;   

DOI  :  10.1515/amm-2015-0364

学科分类：金属与冶金

来源: Akademia Gorniczo-Hutnicza im. Stanislawa Staszica / University of Mining and Metallurgy

【 摘 要 】

The purpose of this paper is to present the innovative design of microwave plasma system for modification of detonation nanodiamond particles (DNP) using a special rotating drum placed inside the reactor. Nanodiamond particles manufactured by detonation method reveal the biological activity depending on surface functionalization. Plasmachemical modification of detonation nanodiamond particles gives the possibility of controlling surface of nanodiamonds particles in biological tests. In this paper we would like to compare detonation nanodiamond (the grain sizes from 2 to 5 nm) with modified detonation nanodiamond in rotary reactor chamber, by microwave plasma activated chemical vapour deposition (MW PACVD) method in materials research (Raman and FT-IR spectroscopy) and in vitro examinations with full of human blood. The results indicate haemocompatibility of non-modified detonation nanodiamond and modified nanodiamond by MW PACVD method in rotary reactor chamber (modified ND-3) and the presence of haemolysis in commercial detonation nanodiamond.

【 授权许可】

Unknown