Study of vitamin D3 level in patients with diabetes mellitus

International Journal of Biomedical and Advance Research

Mayur Goradhanbhai Makadia ; Vishwal Indravadan Patel ; Kinjal Prahaladbhai Patel ; Aashna Darshanbhai Shah ; Kaushik Salubhai Chaudhari ; Haridas Neelakandan Nilayangode

关键词: s Vitamin D3, Glycated Hemoglobin (HbA1c), Diabetes Mellitus;   

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

Introduction: Glycated hemoglobin (HbA1c) is primarily measured to identify glycemic control in diabetic patients. According to The American Diabetes Association (ADA), and World Health Organization (WHO), HbA1c concentrations 6.5% or more is diagnostic of diabetes. Vitamin D3 deficiency has high prevalence all over the India. It has been proposed that mild to moderate vitamin D3 deficiency is a risk factor for type 2 diabetes and higher plasma vitamin D3 is related to a lower risk for the development of diabetes mellitus in high-risk patients. Aim and Objectives: The aim was to study the levels of vitamin D3 and relationship between the levels of vitamin D3 and HbA1c in diabetic patients. Material and Method: HbA1c and vitamin D3 were measured in 100 diabetic patients, and another 100 age and sex matched normal healthy individuals. HbA1c was measured by Immunoturbidimetry and vitamin D3 was measured by Electrochemiluminescence. Results: The mean vitamin D3 level in diabetic patients (27.19 6.03 nmol/L) was significantly lower than healthy individuals (61.13 10.85 nmol/L) (P <0.001). There was an inverse correlation between the levels of vitamin D3 and HbA1c (Pearsons correlation coefficient, r = -0.63, P <0.001). Conclusion: Vitamin D3 levels are deficient in diabetic patients, and there is an inverse correlation between the levels of vitamin D3 and HbA1c. So, the level of vitamin D3 is inversely associated with glycemic control in diabetic patients. Therefore, vitamin D3 supplementation may be helpful in the treatment of Diabetes Mellitus.

【 授权许可】

CC BY