SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF THIOCOLCHICOSIDE AND DEXKETOPROFEN TROMETAMOL IN PHARMACEUTICAL DOSAGE FORM

International Journal of Biomedical and Advance Research

JalpeshT Bharatbhai Trivedi

关键词: s NSAIDS;    Thiocolchicoside;    DexketoprofenTrometamol;   

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

The present manuscript describes simple, sensitive, rapid, accurate, precise and economic dual wavelength spectrophotometric method for simultaneous determination of Thiocolchicoside and Dexketoprofen trometemol in combined tablet dosage form. The utility of dual wavelength data processing program is its ability to calculate unknown concentration of components of interest in a mixture containing an interfering component. The method was based on property of additivity of absorbances. The two wavelengths on UV spectrum of Thiocolchicoside were found out where it showed same absorbance, which were 368 nm and 284.60 nm. At 368 nm Thiocolchicoside showed some absorbance whereas Dexketoprofen trometemol showed zero absorbance. Both the drugs gave absorbance at 284.60 nm. The method involved solving of an equation based on measurement of absorbances at two wavelengths 284.6 and 368 nm. The two drugs follow Beer-Lambert’s law over the concentration range of 2-24 µg/ml. The method was successfully applied to pharmaceutical dosage form because no interference from the tablet excipients was found. The results of analysis have been validated statistically and by recovery studies.

【 授权许可】

CC BY