Serum levels of copeptin, C-reactive protein and cortisol in different severity groups of sickle cell anaemia

Nigerian Journal of Physiological Sciences

关键词: Copeptin;    Cortisol;    Severitry score;    Sickle cell anaemia;    Systolic blood pressure;    Vaso-occlusive crisis;   

学科分类：内科医学

来源: University of Calabar

【 摘 要 】

It is well known that individuals with SCA undergo constant physiological stress even, in steady state. However, there is little information on the relationship between the severity of sickle cell anaemia (SCA) and serum levels of biomarkers of stress. This study therefore determined the serum levels of copeptin, cortisol and CRP in adults with SCA in different severity groups. Sixty adults with sickle cell anaemia in steady state (27.1±6.3 years) and in vaso-occlusive crisis (24.9±4.9 years) were recruited into this cross-sectional study. Degree of severity (mild, moderate or severe) was determined using a scoring system incorporating annual number of blood transfusions, crisis and presence of anaemia, vaso-occlusive pain and organ complications. Standard methods were used for the determination of packed cell volume (PCV), total white blood cell count (WBC), blood pressure measurements and anthropometric indices. Serum levels of copeptin, cortisol and CRP were determined using ELISA with the ratios calculated accordingly. Data obtained were statistically analyzed using the Student’s t-test, Mann Whitney

【 授权许可】

Unknown