Instrumental characterization of the smectite clay–gentamicin hybrids

Bulletin of Materials Science

关键词: Clay mineral;    drug carrier;    intercalation;    XRD;    FTIR.;   

学科分类：材料工程

来源: Indian Academy of Sciences

【 摘 要 】

This paper focusses on the intercalation of clay mineral with gentamicin (an aminoglycoside antibiotic). The smectite clay–gentamicin hybrids were prepared by a solution intercalation at 60°C and the process was carried out on unmodified smectite clay and on smectite after Na+ ionic activation. The resulting structural/microstructural properties and the potential for introducing gentamicin between smectite clay layers were investigated by means of X-ray diffraction, Fourier transform infrared spectroscopic techniques and transmission electron microscopy and scanning electron microscopy with energy-dispersive spectroscopy X-ray analysis. The results confirm the successful intercalation of gentamicin into the interlayer space of smectite clay, demonstrating that the material thus obtained could potentially be used as a drug carrier.

【 授权许可】

CC BY