Cholesterol Levels in Patients with Chronic Lymphocytic Leukemia

National Medical Association. Journal

GurhanKadıkoylu¹  GokhanPektas¹  ZahitBolaman¹  IrfanYavasoglu²  GokhanSargin³  GuvenCetin⁴  GulsumAkgun⁵  OktayBilgir⁵  BilaToka⁶  SehmusErtop⁶  OrhanAyyildiz⁷  SinanDal⁷  AyhanDonmez⁸  MuratTombuloglu⁸  FergunYilm az⁹  Zeynep ArzuYegin^1,10  SerminAltındag^1,11  HasanOzbas^1,12  MehmetSonmez^1,12  AnilTombak^1,13  NaciTiftik^1,13 

[1] Adnan Menderes University, Faculty of Medicine, Department of Internal Medicine, Aydin, Turkey;Adnan Menderes University, Faculty of Medicine, Department of Internal Medicine,Aydin, Turkey;Adnan Menderes University, Faculty of Medicine, Department ofInternal Medicine, Aydin, Turkey;Bezmialem University, Faculty of Medicine, Division of Hematology, Istanbul, Turkey;Bozyaka Training and Research Hospital, Izmir, Turkey;Bülent Ecevit University, Faculty of Medicine, Division of Hematology, Zonguldak, Turkey;Dicle University, Faculty of Medicine, Division of Hematology, Diyarbakir, Turkey;Ege University, Faculty of Medicine, Division of Hematology, Izmir, Turkey;Ege University, Faculty of Medicine, Divisionof Hematology, Izmir, Turkey;Gazi University, Faculty of Medicine, Division of Hematology, Ankara, Turkey;Gazi University, Faculty of Medicine, Divisionof Hematology, Ankara, Turkey;Karadeniz University, Faculty of Medicine, Division of Hematology, Trabzon, Turkey;Mersin University, Faculty of Medicine, Division of Hematology, Mersin, Turkey

关键词: Blood lipid profiles;    Cholesterol levels;    Chronic lymphocytic leukemia;   

DOI  :  10.1016/j.jnma.2016.11.006

学科分类：医学（综合）

来源: Elsevier

【 摘 要 】

Low cholesterol levels may be accompanied by solid tumors or hematological malignancies such as multiple myeloma. Decreased cholesterol levels have been reported in some experimental studies about chronic lymphocytic leukemia (CLL). It may be associated with tumoral cell metabolism. Herein, we examine blood lipid profiles of patients with newly diagnosed CLL (284 male, 276 female, mean age 64 ± 11 years) as defined by National Cancer Institute criteria. The control group consisted of 71 healthy subjects with mean age 55 ± 9 years (28 male, 43 females). 60% of patients with Binet A, while 25% were Binet C. Decreased levels of total cholesterol, high density lipoprotein (HDL) and low density lipoprotein (LDL) were observed in patients with CLL than control group (p < 0,001). There was no statistical significance between CLL and control group for triglycerides (TG) and very low density lipoprotein (VLDL), also between HDL-C, VLDL, TG and grades. Cholesterol may metabolized by abnormal lymphocytes in CLL patients.

【 授权许可】

Unknown