Potential role of cyclophilin A in regulating cytokine secretion

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

Khattak, Muhammad Nasir Khan¹  Mei, Jie¹  Lin, Li⁴  Xiong, Yang⁵  Li, Jun⁶ 

[1] and;..College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, China;..Department of Applied Biology, College of Sciences, University of Sharjah, Sharjah, United Arab Emirates;College of Fisheries, Huazhong Agricultural University, Wuhan, Hubei, China;Department of Zoology, Hazara University, Mansehra, Khyber Pakhtunkhwa, Pakistan;School of Biological Sciences, Lake Superior University, Sault Ste Marie, Michigan, USA

关键词: CD147;    inflammation;    diseases;    mechanism;   

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Cyclophilin A (CypA), a peptidylprolyl cis-trans isomerase, is a ubiquitous and multifunctional protein. In addition to its role as a host-cell receptor for cyclosporine A, CypA has diverse functions in inflammatory conditions and diseases. CypA secreted in response to inflammatory stimuli binds to the cell surface via its receptor CD147 and induces secretion of various inflammatory cytokines. However, silencing and inhibition of either CypA or CD147 inhibits inflammatory cytokine expression and inflammation. This report reviews the literature related to the mechanism of CypA-dependent cytokine secretion and discusses this factor as a possible therapeutic target in inflammatory diseases.

【 授权许可】

CC BY