Complexation of poorly water soluble drug norfloxacin with cyclodextrin

International Journal of Biomedical and Advance Research

Rahul Sharma ; Ritesh S. Bathe

关键词: s Complexation, Cyclodextrin (CD),Inclusion,Norfloxacin, Solubility.;   

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

The aim of the present study is to enhance the solubility and dissolution rate of poorly water soluble drug of Norfloxacin with Cyclodextrn by direct compression method. The adding a water-soluble polymer, like PVP and HPMC, with the aim to increase the aqueous solubility of both the complex and the drug itself. The prepared tablets were evaluated for all pre-compression parameters and post-compression parameters. The drug-excipients interaction was investigated by FTIR. All formulation showed compliances with Pharmacopoeial standards. The study reveals that formulations prepared by direct compression F5 exhibits highest dissolution using crospovidone showed faster drug release 98.33 % over the period of 60 minutes while disintegration time of the tablet was showed 2 minutes comparison to other formulations.

【 授权许可】

CC BY