Biocompatibility Issue Of Tissue Engineered Heart Valves

Archives of Metallurgy and Materials

P. Wilczek¹ 

[1] HEART PROSTHESIS INSTITUTE, BIOENGINEERING LABORATORY, 345A WOLNOSCI STR., ZABRZE 41-800 POLAND;

关键词: Keywords: tissue engineering;    heart valve;    cytotoxicity;    scaffold;   

DOI  :  10.1515/amm-2015-0372

学科分类：金属与冶金

来源: Akademia Gorniczo-Hutnicza im. Stanislawa Staszica / University of Mining and Metallurgy

【 摘 要 】

Tissue engineering is a new field of knowledge which creates the possibilities for producing bioactive cardiac prostheses that will characterize by biomechanical and morphological properties similar to native tissue. It is expected that it will be characterized by high durability, which is very important from the social and clinical point of view. The aim of the study was to compare the cytotoxic effect of enzymatic and detergent acellularization methods commonly used for the biological scaffold preparation. It seems that the use of enzymatic methods, allows efficient donor cells removal while maintaining the ability to autologous cell seeding. Heart valves bioprosthesis created using these techniques, may be a good alternative to the currently used prostheses.

【 授权许可】

Unknown