Roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of innate and innate-like lymphocytes

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

Blumenthal, Antje² 

[1] and..Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland, Australia;The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia

关键词: innate lymphoid cell;    NK cell;    NKT cell;    γ    δ    T cell;    marginal zone B cell;    B1 cell;   

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Innate lymphoid cells (ILCs) and innate-like lymphocytes have important roles in immune responses in the context of infection, cancer, and autoimmunity. The factors involved in driving the differentiation and function of these cell types remain to be clearly defined. There are several cellular signaling pathways involved in embryogenesis, which continue to function in adult tissue. In particular, the WNT, NOTCH, and Hedgehog signaling pathways are emerging as regulators of hematopoietic cell development and differentiation. This review discusses the currently known roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of ILCs and innate-like lymphocytes.

【 授权许可】

CC BY