Neutron structure of human carbonic anhydrase II in complex with methazolamide: mapping the solvent and hydrogen-bonding patterns of an effective clinical drug

IUCrJ

Kovalevsky, A.Y.¹  Aggarwal, M.¹  Velazquez, H.²  McKenna, R.²  Fisher, S.Z.³  Smith, J.C.⁴ 

[1] Biology and Soft Matter Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA;Center for Molecular Biophysics, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA;Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA;Scientific Activities Division, European Spallation Source, 22100 Lund, Sweden

关键词: HUMAN CARBONIC ANHYDRASE;    ACETAZOLAMIDE;    METHAZOLAMIDE;    NEUTRON STRUCTURE;    DRUG BINDING;   

DOI  :  10.1107/S2052252516010514

学科分类：数学（综合）

来源: International Union of Crystallography

【 授权许可】

CC BY