Synthesis, Antimicrobial Activities of New Sulfonamidobenzoxazoles and Molecular Docking Studies on Escherichia coli TEM-1 β-Lactamase

Croatica Chemica Acta

Aki-Yalcin, Esin¹  Yalcin, Ismail¹  Bolelli, Kayhan¹  Ertan-Bolelli, Tugba¹  Kaynak-Onurdag, Fatma²  Okten, Suzan² 

[1] Department of Pharmaceutical Chemistry, Ankara University, Faculty of Pharmacy, Ankara, Turkey;Department of Pharmaceutical Microbiology, Trakya University, Faculty of Pharmacy, Edirne, Turkey

关键词: antimicrobial activity;    benzoxazole;    Escherichia coli;    β-lactamase;    molecular docking;    sulfonamide;   

DOI  :  10.5562/cca3111

学科分类：化学（综合）

来源: Croatica Chemica Acta

【 摘 要 】

β-Lactam antibiotics are frequently used for treatment of multi-drug resistant microbial infections and the most common mechanism of resistance against these antibiotics is bacterial β-lactamase production. Herein, we reported the design, synthesis and in vitro antimicrobial activities of some new 2-substituted-5-(2,4-dinitrophenylsulfonamido)benzoxazole derivatives. Compounds TN1, TN2, and TN3 were found to be significantly active against E. coli isolate which contains extended spectrum β-lactamase enzyme at the MIC value of 8 µg mL–1 and that is

【 授权许可】

CC BY