Testicular Leiomyosarcoma in an SMP30 Knockout Mouse

Pakistan Veterinary Journal

Kyu-Shik Jeong¹  Jin-Kyu Park² 

[1] Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, 702-701, Republic of Korea

关键词: Mouse;    SMP30;    Testicular leiomyosarcoma;    Vimentin;    α-SMA;   

学科分类：兽医学

来源: University of Agriculture * Faculty of Veterinary Science

【 摘 要 】

Reports of testicular leiomyosarcoma are extremely rare in the veterinary literature. Here we report a case of testicular leiomyosarcoma occurring in a 32-weeks-old male senescence marker protein 30 (SMP30) knockout mouse. Grossly, a testicular mass completely replaced the right testis. The mass had a diameter of 1.6×0.9cm, and was well-encapsulated and firm. The cut surface showed heterogeneous white and yellow-brownish components with multifocal hemorrhages. Microscopically, the mass was composed ofinterlacing bundles ofneoplasticcells characterized by a spindle-shaped appearance with elongated blunt-end nuclei and frequently observed mitotic figures.Immunohistochemically, the neoplastic cells showed strong positivity for vimentin and α-smooth muscle actin. Finally, present case was diagnosed as testicular leiomyosarcoma in an SMP30 knockout mouse.

【 授权许可】

CC BY-NC