Epitranscriptome and FMRP Regulated mRNA Translation

Epigenomes

Majumder, Pritha¹ 

关键词: epitranscriptome;    FMRP;    TDP-43;    RNA methylation;    RNA editing;    dendritic local translation;    neurological diseases;   

DOI  :  10.3390/epigenomes1020011

学科分类：分子生物学，细胞生物学和基因

来源: mdpi

【 摘 要 】

An important regulatory mechanism affecting mRNA translation involves various covalent modifications of RNA, which establish distinct epitranscriptomic signatures that actively influence various physiological processes. Dendritic translation in mammalian neurons is a potent target for RNA modification-based regulation. In this mini-review, we focus on the effect of potential RNA modifications on the spatiotemporal regulation of the dendritic translation of mRNAs, which are targeted by two important neuronal translational co-regulators, namely TDP-43 and Fragile X Mental Retardation Protein (FMRP).

【 授权许可】

CC BY