Swift and Strong NK Cell Responses Protect 129 Mice against High-Dose Influenza Virus Infection

The Journal of Immunology: Official Journal of the American Association of Immunologists

George Fu Gao¹  Wenming Zhao¹  Jing Wang¹  Wei Zhang²  Min Fang³  Jinghua Yan³  An Li³  Kai Zhou³  Wenjun Liu⁴  Dongfang Wang⁵ 

[1]and

[2]Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

[3]College of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning 530004, China

[4]University of Chinese Academy of Sciences, Beijing 100049, China

DOI  :  10.4049/jimmunol.1501486

学科分类：生物科学（综合）

来源: American Association of Immunologists

【 摘 要 】

It is generally unclear what roles NK cells play during influenza virus infection with regard to different host genetic backgrounds. In this study, we show that in six inbred mouse strains, NK cells play an important protective role only in 129 mice during high-dose influenza A H1N1 virus infection. Swift and strong NK cell responses efficiently control early pulmonary viral replication in 129 mice, providing survival privilege. In addition, we identified that early activation of TLRs and RIG-I signaling in 129 mice resulted in quick production of type 1 IFNs and inflammatory cytokines, which are important reasons for the swift kinetics of NK cell responses post influenza virus infection. Thus, under different microenvironments, NK cells play differential roles against viral infections. The kinetics and magnitude of NK cell responses correlate with the distinct roles that NK cells play against influenza virus infections. Thus, our works further our understandings about the complex role of NK cells during influenza virus infection.

【 授权许可】

CC BY