Understanding the Entanglement: Neutrophil Extracellular Traps (NETs) in Cystic Fibrosis

Frontiers in Cellular and Infection Microbiology

Martí¹  ndez-Bello, Romel¹  a, Lizbeth¹  nchez-Gonzá¹  Gonzá²  lez, Alejandro²  Palma-Nicolas, José²  nez-Alemá²  Herná³  Campos-Garcí³  Sá³  n, Saira R.⁴  P.⁴  lez, Gloria M.⁴ 

[1] Departamento de Microbiología, Facultad de Medicina, Universidad Autón, Monterrey, Mexico;noma de Nuevo Leó

关键词: Neutrophil;    NETs;    Cystic Fibrosis;    CFTR;    Pseudomonas aeruginosa;    Staphylococcus aureus;    Burkholderia cepacia;   

DOI  :  10.3389/fcimb.2017.00104

学科分类：生物科学（综合）

来源: Frontiers

【 摘 要 】

Cystic fibrosis is an autosomal recessive disorder caused by mutations in the gene that codes for the cystic fibrosis trans-membrane conductance regulator. These mutations result in abnormal secretions viscous airways of the lungs, favoring pulmonary infection and inflammation in the middle of neutrophil recruitment. Recently it was described that neutrophils can contribute with disease pathology by extruding large amounts of nuclear material through a mechanism of cell death known as Neutrophil Extracellular Traps into the airways of patients with cystic fibrosis. Additionally, NETs production can contribute to airway colonization with bacteria, since they are the microorganisms most frequently found in these patients. In this review, we will discuss the implication of individual or mixed bacterial infections that most often colonize the lung of patients with cystic fibrosis, and the NETs role on the disease.

【 授权许可】

CC BY