Evaluation of prunes for hypotensive, angiotensin converting enzyme (ACE) inhibitory and diuretic activities in rats

Dynamic Chiropractic

关键词: Prunes;    Prunus domestica;    hypotensive;    angiotensin converting enzyme (ACE) inhibition;    diuretic.;   

DOI  :  10.5897/JMPR11.1558

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Prunes are dried fruits of several species of Prunus, including that ofPrunus domesticaLinn (Rosaceae) and are used for the treatment of hypertension in traditional systems of medicine in India and Pakistan. We investigated the blood pressure lowering, angiotensin converting enzyme (ACE) inhibitory and diuretic activities of the aqueous-methanolic crude extract of dried fruits ofP. domestica(Pd.Cr.) in rats. Intravenous administration of the Pd Cr decreased mean arterial blood pressure, systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the ketamine-diazepam anesthetized normotensive rats dose-dependently, at the dose range of 1 to 30 mg/kg.In vitro, the extract was fond to have serum ACE inhibitory activity, with IC50value of 1.102 mg/ml. The extract did not increase urine output in rats. The study concludes that the crude extract of prunes has hypotensive and ACE inhibitory activities, which provides scientific justification for its traditional uses as cardioprotective and antihypertensive remedy.

【 授权许可】

Unknown