IFITM3 Rs12252-C Variant Increases Potential Risk for Severe Influenza Virus Infection in Chinese Population

Frontiers in Cellular and Infection Microbiology

Dong, Tao¹  Peng, Xiaomin¹  Zhang, Daitao²  Pan, Yang²  Wang, Quanyi²  Zhang, Yi²  Liu, Yimeng²  Cui, Shujuan³  Shi, Weixian⁴  Lu, Guilan⁴  Yang, Peng⁴  Wu, Shuangsheng⁴ 

[1] Capital Medical University School of Public Health, Beijing, China;Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, China;MRC Human Immunology Unit, Weather all Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom;Research Centre for Preventive Medicine of Beijing, Beijing, China

关键词: influenza;    Interferon Inducible Transmembrane 3;    Single nucleotide polymorphism;    severe acute respiratory infection;    Genetic Susceptibility;   

DOI  :  10.3389/fcimb.2017.00294

学科分类：生物科学（综合）

来源: Frontiers

【 摘 要 】

Background Interferon Inducible Transmembrane 3 (IFITM3) is a key factor in interferon pathway and it involves host's immune response against multiple viruses. IFITM3 rs12252-C was associated with severe influenza virus infection in several studies, however whether this association is universal to all types of influenza virus or diverse ethnic populations remain controversial. Method A case-control genetic association study was performed from September 2013 to April 2014 and September 2014 to April 2015. All samples were tested for influenza using RT-PCR, and genotyped by High Resolution Melting assay. Results A total of 65 healthy people, 165 mild influenza-like illness (ILI) cases and 315 Severe Acute Respiratory Infection (SARI) cases were enrolled in this study. The frequency of CC genotype was much higher in SARI cases with IVI than that in ILI cases with IVI (61.59% vs. 27.16%), leading a 4.67-fold greater risk for severe IVI than other two genotypes. Moreover, the risk of IFITM3 rs12252-C variant for severe IVI was specific for both influenza A and influenza B. Conclusion IFITM3 rs12252 CC genotype was associated with severity rather than susceptibility of IVI in Chinese population, and this strong effect was observed in all subtypes of seasonal influenza infection.

【 授权许可】

CC BY