Effects of Lonicera japonica Thunb. on dextran sulfate sodium-induced experimental colitis in mice

Dynamic Chiropractic

Ki - Hyeong Rhee¹  Kyung-Sook Whang²  Keyong Ho Lee³ 

[1] College of Industrial Sciences, Kongju National University, Yesan 340-702, Korea.;Department of Microbiol and Nano Materials, Mokwon University, Daejeon, 302-729, Korea.;Kolon Life Science Inc., Yongin City, 446-797, Korea.

关键词: Lonicera japonica;    dextran sulfate sodium;    inflammatory bowel disease.;   

DOI  :  

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

We investigated the effects of buthanol (BuOH) extracts ofLonicera japonicaon dextran sulfate sodium (DSS)-inducedq mice colitis. Body weight, histological indices such as crypt injury and inflammation score, biochemical factor such as serum amyloid (SAA) and MPO level data were evaluated. BuOH extracts ofL. japonicareduced the crypt injury and inflammation score and showed markedly greater more decreases of the SAA and MPO levels relative to the 5-ASA group. In addition, BuOH extracts will reduce the level of IL-6 which is stimulated by a lipopolysaccharide (LPS) in the HT-29 cell linein vitro. Therefore, BuOH extracts ofL. japonicamay be useful as apotential inhibitorfor preventing inflammatory bowel disease in humans.

【 授权许可】

Unknown