Rab GTPases in Immunity and Inflammation

Frontiers in Cellular and Infection Microbiology

Prashar, Akriti¹  Bernard, Elliott M.¹  Gutierrez, Maximiliano G.¹  Schnettger, Laura¹ 

[1] Host-Pathogen Interactions in Tuberculosis Laboratory, Francis Crick Institute, United Kingdom

关键词: Rab GTPase;    Macrophages;    Phagosomes;    Inflammation;    innate immunity;   

DOI  :  10.3389/fcimb.2017.00435

学科分类：生物科学（综合）

来源: Frontiers

【 摘 要 】

Strict spatiotemporal control of trafficking events between organelles is critical for maintaining homeostasis and directing cellular responses. This regulation is particularly important in immune cells for mounting specialized immune defences. By controlling the formation, transport and fusion of intracellular organelles, Rab GTPases serve as master regulators of membrane trafficking. In this review, we discuss the cellular and molecular mechanisms by which Rab GTPases regulate immunity and inflammation.

【 授权许可】

CC BY