Piper sarmentosum Roxb protects lungs against oxidative stress induced by carbon tetrachloride in rats

Dynamic Chiropractic

Reeny FA Rahman¹  Yusof Kamisah²  Mohd Fahami Nur Azlina³ 

[1] Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.;Department of Biomedical Sciences, Faculty of Health Allied Science, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.;Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

关键词: Piper sarmentosum;    oxidative stress;    antioxidant;    carbon tetrachloride.;   

DOI  :  10.5897/JMPR10.054

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

This study was designed to investigate the effects ofPiper sarmentosumsupplementation on carbon tetrachloride (CCl4) induced oxidative stress in lung. Thirty-two male Wistar rats were divided into two groups; a control and a treatment group which was given 125 mg/kg body weightP. sarmentosumorally for 28 days, after which each group was further subdivided into two groups. A group was exposed to CCl4(1 ml/kg body weight, orally),while another group was given corn oil. After 24 h, blood and lung were taken. CCl4increased lung lipid peroxidation (TBARS) and glutathione peroxidase significantly.P. sarmentosumsupplementation was able to reduce these increases. However, both CCl4andP. sarmentosumextract did not affect lung superoxide dismutase activity. In conclusion,P. sarmentosumis capable in reducing the oxidative stress in lungs by decreasing lipid peroxidation and maintaining the glutathione peroxidase activity towards the normal level.

【 授权许可】

Unknown