Zingiber officinale extract modulates g-rays-induced immunosuppression in mice

Dynamic Chiropractic

关键词: Zingiber officinaleextract;    g-rays;    immunosuppression;    IL-1b;    IL-3;    micronuclei.;   

DOI  :  10.5897/JMPR10.314

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Zingiber officinaleextract (ZOE), has been demonstrated to ameliorate the symptoms of radiation sickness and mortality induced by the gamma-irradiation in mice. In this study, we further investigated the immune-modulator potential of ZOE against the immunosuppression. Compared to mice irradiated alone, ZOE treatment significantly increased the spleen relative weight of the mice. Moreover, ZOE treatment enhanced the cellular immune response characterized by higher macrophage, splenocyte survival, splenocyte proliferation and higher ratio of CD4+ and CD8+. In addition, ZOE improved the humoral response represented by the higher antibody titers of I gG, I gA and I gM and up-regulated the secretion of cytokines such as IL-1band IL-3. Furthermore, ZOE treatment significantly reduced the numbers of micronuclei (MN) in bone marrow polychromatic erythrocytes (PCEs). Collectively, these finding indicated that ZOE has the regulatory effect againstg-rays-induced immun-suppression by means of protecting DNA against the radiation.

【 授权许可】

Unknown