Study on Cell-Capturing Microfluidic Device in High Flow Rates through Controlling Shape of Microstructures and Their Alignments

Proceedings

Lee, Dae-Sik¹ 

关键词: microfluidic device;    rare cell capturing;    shape control;    high flow rate;   

DOI  :  10.3390/proceedings1040516

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

A new cell-trapping method for single cell analysis devices at a very rapid flow rate, is designed, fabricated and characterized by controlling shapes of microstructures and their arrangements in array just simply and effectively within the microfluidic channels. We simulated using a commercialized computational fluidic dynamic simulator (CFD-ACE+) and demonstrated experimentally that the cell-capturing rate enhanced over three times and a high capturing efficiency of about 70% at a 300 µL/min at the cross-arranged left-turned isosceles trapezoid. The device is applicable for a tool in the field of characterization of rare cells, personal medicine, and prognostic of disease.

【 授权许可】

CC BY