Regional Variations in the Incidence of Rotavirus Hospitalization in Children Living in Defined Regions of Akita and Kyoto Prefectures, Japan

Japanese journal of infectious diseases

Tsutomu Takahashi¹  Toyoko Nakagomi¹  Osamu Nakagomi²  Atsuko Noguchi³  Hisato Ito⁴  Shinobu Miura⁵  Yoshiki Fujii⁶  Kazuhiko Katayama⁶ 

[1] Center for Bioinformatics and Molecular Medicine, Graduate School of Biomedical Sciences, Nagasaki University;Department of Hygiene and Molecular Epidemiology, Graduate School of Biomedical Sciences, Nagasaki University;Department of Pediatrics, Akita University Graduate School of Medicine;Department of Pediatrics, Nantan General Hospital;Department of Pediatrics, Yuri-Kumiai General Hospital;Department of Virology II, National Institute of Infectious Diseases

关键词: rotavirus;    gastroenteritis;    incidence rate;    hospitalization;   

DOI  :  10.7883/yoken.JJID.2016.052

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

Variable incidence rates of rotavirus gastroenteritis hospitalizations have been reported in Japan. However, it is not known whether the observed regional differences were due to the real difference in the occurrence of severe disease or other causes. This study aimed to determine the incidence rates of rotavirus hospitalization among children aged <5 years in the Yuri district in Akita prefecture and the Nantan district in Kyoto prefecture between March 2012 and February 2013. During this period, rotavirus vaccine uptake rates were equally low in both regions. All specimens were evaluated using the standardized case definition, severity scores, and the same assays. There were 44 rotavirus cases (44%) among 101 acute gastroenteritis-related hospitalizations in the Yuri district with a catchment population of 3,853, and 18 rotavirus cases (47%) among 38 acute gastroenteritis-related hospitalizations in the Nantan district with a catchment population of 5,128. While the severity score at the time of the hospitalizations was 11 in both hospitals, the incidence rates in Akita and Kyoto were 11.7 (95% confidence interval [CI]: 8.5–15.6) and 3.9 (95% CI: 2.1–5.5) per 1,000 child-years, respectively. Thus, there was a real difference in the occurrence rate of severe rotavirus infections between the 2 regions.

【 授权许可】

Unknown