In vitro screening of selected Saudi medicinal plants for potential leishmanicidal activity

Dynamic Chiropractic

Nawal Musayeib Al-Musayeib¹ 

关键词: Leishmania;    Cordia;    Caralluma;    Calotropis.;   

DOI  :  10.5897/JMPR12.840

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Leishmaniasis is a group of diseases caused by protozoa of the genusLeishmania. This major world health problem ranks among the six most important tropical infectious diseases by the World Health Organization. The current study was undertaken to exploit the antileishmanic activity of three medicinally active plants of Saudi flora,Calotropis procera,Caralluma sinaicaandCordia sinensisusing 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay. The highest antileishmanial activity againstLeishmania majorwas exhibited at 200 µg/ml byn-hexane fraction ofC. sinaica(81.44% inhibition). Meanwhile, approximately 60% inhibition was shown by chloroform, ethyl acetate,n-butanol and aqueous extracts of this plant.C. proceraextracts showed lower inhibition potency ranging from 47 to 56% of inhibition, compared toC. sinaicaat similar concentration.

【 授权许可】

Unknown