Regulation of macrophage and monocyte immune responses by water extract from the inner bark of Tabebuia avellanedae

Dynamic Chiropractic

Jaehwi Lee¹  Kook Hyun Kim²  Byung Hun Kim³ 

[1] College of Pharmacy, Chung-Ang University, Chuncheon 156-756, Korea.;Gapi-Korea, Seoul 153-803, Korea.;School of Bioscience and Biotechnology and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea.

关键词: Tabebuia avellanedae(Bignoniaceae);    water extract;    macrophages;    monocytes;    cell-to-cell interaction.;   

DOI  :  10.5897/JMPR09.282

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Tabebuiasp. (Bignoniaceae) is representative traditional herbal plants, found in tropical rain forest areas throughout Central and South America. These plants have been mostly used as a folk medicine to treat bacterial infection, blood coagulation, cancer and inflammatory diseases. In this study, we aimed to demonstrate the modulatory role ofTabebuia avellanedaein various macrophage- or monocyte-mediated immune responses using its water extract (Ta-WE). Ta-WE was able to up-regulate cell-cell interaction by decreasing the migration of cells and by enhancing CD29-mediated cell-cell adhesion, and the surface levels of adhesion molecules (CD18, CD29, and CD82) and costimulatory molecules (CD80 and CD86) linked to macrophage stimulation as seen in up-regulation of ROS release. In addition, this fraction also suppressed an alteration in the membrane levels of macrophages such as phagocytic uptake and morphological changes. Therefore, these results suggest that the water extract ofT. avellanedaecan strongly modulate an ability of macrophages and monocytes to manage immune cell-cell interaction in host defence system.

【 授权许可】

Unknown