Anti-inflammatory, analgesic and antioxidant properties of Bursera morelensis bark from San Rafael, Coxcatln, Puebla (Mxico): Implications for cutaneous wound healing

Dynamic Chiropractic

Rocio Serrano Parrales⁴  Margarita Canales Martinez⁵  Beatriz Vazquez Cruz^1,11  Ana Luisa Anaya Lang^1,14  David Segura Cobos^1,15  Manuel Jimenez-Estrada^1,16 

[1] Ciencias BiolóInstituto de EcologíInstituto de QuíLaboratorio de Farmacognosia, UBIPRO, Facultad de Estudios Superiores Iztacala, Universidad Nacional AutóLaboratorio de Farmacología, UIICSE, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autóa, Universidad Nacional Autógicas, Universidad Nacional Autómica, Universidad Nacional Autón, Ménoma de México, Circuito Exterior, Ciudad Universitaria, 04510, México, D. F., México, México, Tlalnepantla 54090, Edo. de México.;xico. Av. Ciudad Universitaria 3000, 04360, Coyoacá

关键词: Bursera morelensis;    anti-inflammatory;    analgesic;    antioxidant;    wound healing;    phenolic compounds;   

DOI  :  10.5897/JMPR11.549

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Bursera morelensisRamírez bark is used by people of San Rafael, Coxcatlán, in Puebla State, México, as a traditional remedy to heal skin wounds. In the present study, we evaluated anti-inflammatory, analgesic and antioxidant activities of the methanolic extract (MP) obtained from the bark. Our results demonstrated that MP ofB. morelensispossesses anti-inflammatory activity by inhibition of paw edema induced by carrageenan in rats. The dose of 50 mg/kg was comparable with indomethacin used as reference standard. The extract (50 mg/kg) also diminished 28.01% of the number of neutrophils migrating into the peritoneal cavity. At the same dose, an analgesic activity of the extract was observed by inhibition of acetic acid induced writhing response in mice. The extract also showed a strong capacity of DPPH radical scavenging with an EC50of 3.05 µg/mL that was comparable with quercetin (EC50= 4.45 µg/mL). The biological activities of the extract are attributed to its mixture of phenolic compounds (50.5%), particularly phenilpropanoids and flavonoids. The anti-inflammatory, analgesic and antioxidant properties shown by the extract favor the wound healing, thus controlling the inflammatory process without inhibiting it. This study supports the traditional use ofB. morelensisbark for the treatment of acute skin wounds.

【 授权许可】

Unknown