Inhibition effects on HBV replication by hydrophobic extracts from Ferula ferulaeoides (Steud.) Korov

Dynamic Chiropractic

H. Q. Xie¹  T. Liu²  L. L. Zhai³ 

[1] Department of Plant Protection, Agricultural School, Shihezi University, Xinjiang 832002, China.;Key Laboratory of Medical Molecular Virology, MOE/MOH, Shanghai Medical College, Fudan University, Shanghai 200032, China.;School of Pharmacy, Fudan University, Shanghai 200032, China.

关键词: Hepatitis B Virus;    anti-HBV;    HBsAg;    Ferula ferulaeoides.;   

DOI  :  10.5897/JMPR11.553

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Hepatitis B virus (HBV) infection is a worldwide public health problem, which can lead to life threatening chronic hepatitis, liver cirrhosis and cancer. Despite this, treatments for chronic HBV infection are still very limited. In our investigation herbal medicines as antiviral agents, FF, the lipid soluble fraction ofFerula ferulaeoides, which has been used as a traditional Chinese medicine, showed a significant inhibitory effect against HBV in HBV-producing cell line HepG2.2.15. In the experiment, FF reduced the HBsAg level and HBV replication by 87% and 36%, respectively. The results suggest the lipophilic fraction of root extractsfromF. ferulaeoidescould serve as a effective natural constituents of herbs for the search of novel anti-HBV agents.

【 授权许可】

Unknown