Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases

Frontiers in Cellular and Infection Microbiology

Johnson, Nicholas¹  Villar, Margarita²  Nijhof, Ard M.²  a, Agustí³  Vancova, Marie³  n, Nieves⁴  Bonnet, Sarah⁵  Rudenko, Nataliia⁵  Mansfield, Karen L.⁶  Papa, Anna⁷  n⁸  Cabezas-Cruz, Alejandro⁹  Kocan, Katherine M.⁹  Torina, Alessandra^1,10  Alberdi, Pilar^1,11  de la Fuente, José^1,13  Fooks, Anthony R.^1,13  Golovchenko, Maryna^1,13  Domingos, Ana G.^1,14  Estrada-Peñ^{1,14  1,15}  Gortazar, Christian^1,15  Grubhoffer, Libor^1,15  Aylló^1,16  Antunes, Sandra^1,17  Caracappa, Santo^1,17  Rego, Ryan O. M.^1,17 

[1] Budějovice, Czechia;Animal and Plant Health Agency, Surrey, UK;Biology Centre, Czech Academy of Sciences, Institute of Parasitology, Ceske Budejovice, Czechia;Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece;Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, USA;Facultad de Veterinaria, Universidad de Zaragoza, Zaragoza, Spain;Faculty of Health and Medicine, University of Surrey, Guildford, UK;Faculty of Science, University of South Bohemia, ČeskéGlobal Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal;Institute for Parasitology and Tropical Veterinary Medicine, Freie UniversitäInstitute of Infection and Global Health, University of Liverpool, Liverpool, UK;National Center of Reference for Anaplasma, Babesia, Rickettsia and Theileria, Intituto Zooprofilattico Sperimentale della Sicilia, Sicily, Italy;SaBio. Instituto de InvestigacióUMR BIPAR INRA-ANSES-ENVA, Maisons-Alfort, France;n en Recursos Cinegét Berlin, Berlin, Germany;ticos CSIC-UCLM-JCCM, Ciudad Real, Spain

关键词: tick;    Anaplasma;    Flavivirus;    Babesia;    Borrelia;    microbiome;    immunology;    Vaccine;   

DOI  :  10.3389/fcimb.2017.00114

学科分类：生物科学（综合）

来源: Frontiers

【 摘 要 】

Ticks and the pathogens they transmit constitute a growing burden for human and animal health worldwide. Vector competence is a component of vectorial capacity and depends on genetic determinants affecting the ability of a vector to transmit a pathogen. These determinants affect traits such as tick-host-pathogen and susceptibility to pathogen infection. Therefore, the elucidation of the mechanisms involved in tick-pathogen interactions that affect vector competence is essential for the identification of molecular drivers for tick-borne diseases. In this review, we provide a comprehensive overview of tick-pathogen molecular interactions for bacteria, viruses and protozoa affecting human and animal health. Additionally, the impact of tick microbiome on these interactions was considered. Results show that different pathogens evolved similar strategies such as manipulation of the immune response to infect vectors and facilitate multiplication and transmission. Furthermore, some of these strategies may be used by pathogens to infect both tick and mammalian host. Identification of interactions that promote tick survival, spread and pathogen transmission provides the opportunity to disrupt these interactions and lead to a reduction in tick burden and the prevalence of tick-borne diseases. Targeting some of the similar mechanisms used by the pathogens for infection and transmission by ticks may assist in development of preventative strategies against multiple tick-borne diseases.

【 授权许可】

CC BY