Pseudomonas aeruginosa Takes a Multi-Target Approach to Achieve Junction Breach

Frontiers in Cellular and Infection Microbiology

Reboud, Emeline²  Golovkine, Guillaume³  Huber, Philippe⁴ 

[1] Grenoble Alpes, France;et de la Recherche MéCentre National de la Recherche Scientifique ERL5261, CEA BIG-BCI, Institut National de la Santédicale UMR1036, Université

关键词: bacterial invasion;    Bacterial virulence factors;    Intercellular Junctions;    Bacterial Secretion Systems;    Epithelium;    Endothelium;   

DOI  :  10.3389/fcimb.2017.00532

学科分类：生物科学（综合）

来源: Frontiers

【 摘 要 】

P. aeruginosa is an opportunistic pathogen which uses a number of strategies to cross epithelial and endothelial barriers at cell-cell junctions. In this review, we describe how the coordinated actions of P. aeruginosa’s virulence factors trigger various molecular mechanisms to disarm the junctional gate responsible for tissue integrity.

【 授权许可】

CC BY