Effect of corn oil, flaxseed oil and black seed oil on lead acetate-induced hepatic tissue damage: A histological study

Dynamic Chiropractic

Saud A. Alarifi¹  Doaa M. El-Nagar²  Badr A. Aldahmash³ 

[1] Department of Zoology, College of Science, King Saud University, Saudi Arabia.;Faculty of Sciences and Humanities, Salman bin Abdul Aziz University, Saudi Arabia.;Medical Laboratory Department, College of Health Sciences, King Saud University, Saudi Arabia.

关键词: Lead acetate;    corn oil;    flaxseed oil;    black seed oil;    liver.;   

DOI  :  10.5897/JMPR12.658

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Lead is considered as one of the major environmental pollutants that continued to pose health hazards in animal and man in many parts of the world. The current study aimed to investigate the histological effects of corn oil, flaxseed oil and black seed oil against lead acetate-induced hepatic tissue damage in mice. Animals were divided into five groups. The first group served as a control group. The second group was inoculated with 20 mg/kg lead acetate. The third, fourth and fifth groups were inoculated with lead acetate then, treated with 1000 mg/kg of corn oil, flaxseed oil and black seed oil, respectively. At day 5 post-treatment, the liver sections were prepared for the histological study. Lead acetate induced severe hepatic tissue damage mainly in the form of inflammatory cellular infiltration, hepatocytic vacuolation and sinusoidal dilatation. Mice treated with corn oil for 5 days still have histopathological lesions. Both flaxseed oil and black seed oil could reduce the lead acetate-induced hepatic tissue damage.

【 授权许可】

Unknown