Dengue Associated Acute Encephalitis Syndrome Cases in Son La Province, Vietnam in 2014

Japanese journal of infectious diseases

Futoshi Hasebe¹  Corazon C. Buerano¹  Mya Myat Ngwe Tun¹  Rohitha V. Muthugala¹  Meng Ling Moi¹  Kouichi Morita¹  Le Thi Hien Thu²  Dang Thi Dinh²  Nguyen Thi Thu Thuy²  Nguyen Viet Hoang²  Le Thi Quynh Mai²  Pham Hoai Linh Ly³ 

[1] Department of Virology, Institute of Tropical Medicine, Nagasaki University;Department of Virology, National Institute of Hygiene and Epidemiology;NIHE-Nagasaki Friendship Laboratory, Nagasaki University

关键词: Japanese encephalitis;    Dengue;    Acute encephalitis;    ELISA;    Neutralization test;   

DOI  :  10.7883/yoken.JJID.2016.246

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

Acute encephalitis syndrome (AES) is associated with high morbidity and mortality, and affects both children and adults. The main etiologic agent is Japanese encephalitis virus (JEV); however, there are also reports of Dengue virus (DENV) encephalitis. The objectives of this study were to determine the proportion of patients with encephalitis due to JEV during the 2014 outbreak in Son La Province in Vietnam and to explore the association of DENV in non-JEV viral encephalitis cases. Of 90 patients, 6 (6.7%) were positive for anti-JEV immunoglobulin M (IgM), 5 (5.6%) were positive for anti-DENV IgM, 30 (33.3%) were positive for both anti-JEV and anti-DENV IgM, and 56 (62.2%) were positive for flavivirus immunoglobulin G (IgG). In 5 patients with AES, who had positive anti-DENV IgM results in at least one of the paired serum samples, DENV was confirmed by neutralization testing. The incidence of JEV infection was high. There is still a need to maintain and strengthen the national JEV immunization program. This noticeable occurrence of DENV infection was not reported in Son La Province in 2013–2014. Our data suggested that in addition to JEV, DENV was also a causative agent of AES in 2014 in Son La Province, and this finding also confirmed the local occurrence of DENV infection.

【 授权许可】

Unknown