Current oncology | |
Carcinoma ex pleomorphic adenoma: case report and options for systemic therapy | |
N. Chooback1  C. Ho1  J. Laskin1  M. Martin1  T. Thompson1  M. Marra2  M. Jones2  K. Kasaian2  Y. Shen2  T. Ng3  | |
[1] BC Cancer Agency;BC Cancer Research Centre;Vancouver Coastal Health Research Institute | |
关键词: Carcinoma ex pleomorphic adenoma; chemotherapy; cyclophosphamide; doxorubicin; cisplatin; | |
DOI : 10.3747/co.24.3588 | |
学科分类:肿瘤学 | |
来源: Multimed, Inc. | |
【 摘 要 】
The most common benign salivary tumour is a pleomorphic adenoma. Transformation to malignancy, carcinoma ex pleomorphic adenoma (cxpa), occurs in 6% of cases. Management focuses on surgical resection and radiotherapy; however, rare cases require systemic management. We present the case of a 60-year-old woman with a cxpa of the left parotid gland who required systemic therapy for locally recurrent disease. Treatment options were guided by the literature concerning malignant salivary gland tumour and by whole-genome and transcriptome sequencing of the tumour. The patient received multiple systemic agents during the course of her disease, with cyclophosphamide–doxorubicin–cisplatin providing the best control (partial response). Genomeand transcriptome-directed therapy, including sorafenib and vismodegib, were utilized with limited clinical benefit. Malignant transformation in cxpa is a complex process, and therapy directed at a single tumour pathway might not be sufficient to control disease.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201902025790474ZK.pdf | 771KB | download |