Antiviral activity of crude extracts of Synadenium glaucescens (Pax) against infectious bursal disease and fowlpox virus

Dynamic Chiropractic

Faith Philemon Mabiki¹  Robinson H. Mdegela²  Resto D. Mosha³ 

[1]Faculty of Science, Sokoine University of Agriculture, P. O. Box 3038, Solomon Mahlangu Campus, Morogoro, Tanzania.

[2]Faculty of Veterinary Medicine, Sokoine University of Agriculture, P. O. Box 3015, Chuo Kikuu, Morogoro, Tanzania.

[3]Instute of Traditional medicine Department of Natural Product Development and Formulation, Muhimbili University of Health and Applied Sciences, P.O. Box 65001 Dar Es salaam Tanzania.

关键词: Chicken;    gumboro;    Fowlpox disease;    liyugi;    mvunjakongwa and viral infection.;   

DOI  :  10.5897/JMPR12.777

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

The effect of crude extracts from different morphological parts ofSynadenium glaucescensagainstinfectious bursal disease virus (IBDV) and fowlpox (FP) virus using anin ovoassay were investigated. Viable 9 days embryonated chicken eggswere challenged with viral strains then treated withS. glaucescensextracts at concentration of 0.2 mg/ml.Un-inoculated group were saved as negative control and groups inoculated with virus and diluent saved as positive controls. The treatments were observed daily and embryo weights were measured5 days post-inoculation. Embryo survival and mean embryo weight were significantly higher (P ≤0.001) in groups treated withS. glaucescensextractsthan the positive control. More than 50% of the extract prevented death and deformation of embryo and formation of pock lesions in embryos. Furthermore, the treatments with ethanolic extract of the root bark demonstrated significantly higher mean embryo weight compared to other extract for both viruses (P≤ 0.001). The mean embryo weights from eggs challenged withinfectious bursal disease virus and fowlpox virustreated with the extract were 6.3 ± 2 and 5.9 ± 0.5 g, respectively.These findings demonstrate potential and feasibility of usingS. glaucescensextracts fortreatment of the viral diseases. Furthermore, it validates the ethnoveterinaryexploitation at community level.

【 授权许可】

Unknown