Molecular mechanisms that underlie the sexual stimulant actions of ginger (Zingiber officinale Rosocoe) and garden rocket (Eruca sativa L.)

Dynamic Chiropractic

关键词: Ginger;    garden rocket;    Eruca sativa;    Zingiber officinale;    sexual behavior;    intracavernosal pressure;    cyclic GMP (cyclic guanosine monophosphate);    dihydrotestosterone.;   

DOI  :  10.5897/JMPR12.821

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

The effects of extracts and subfractions ofZingiber officinalerhizomes,Eruca sativaseeds and sildenafil on the sexual behavior of male rats and their effects on the intracavernosal pressure (ICV), intracavernosal cycliccyclic guanosine monophosphate(GMP) and dihydrotestosterone plasma level were examined. The sexual behavior was followed for four hours using infra-red video cameras to quantify the effects on various male sexual behaviors. The results revealed that the active subfraction in case ofZ. officinalewas the hexane fraction of the chloroformic extracts (C/H) whereas that ofE. sativaseeds was the acetonitrile fraction of the alcoholic extracts (A/Ac). (C/H), (A/Ac) and sildenafil significantly increased the total sexual stimulation index from 53.8 ± 2.7 (control) to 116 ± 3.8, 253 ± 2.7 and 401 ± 30.1, respectively. They significantly increased the index of successful mounting and ejaculation from 2.6 ± 0.5 (control) to 19 ± 0.5, 13 ± 0.6 and 18 ± 1.7, respectively. They significantly increased the cyclic GMP level from 0.94 ± 0.07 (control) to 2.81 ± 0.19, 2.65 ± 0.14 and 3.66 ± 0.19 ng/mg wet weight tissue, respectively. Furthermore, (C/H) increased plasma dihydrotestosterone level. Other treatments did not affect this parameter. (C/H), (A/Ac) and sildenafil increased the (I.CV) pressure. Both extracts and sildenafil acted via an increase in cyclic GMP with an additional increase in dihydrotestosterone release in case of (C/H).

【 授权许可】

Unknown