Evaluation of the hepatoprotective activity of standardized ethanolic extract of Curcuma xanthorrhiza Roxb.

Dynamic Chiropractic

关键词: Curcuma xanthorrhiza;    hepatoprotective activity;    ethanol;    serum enzyme.;   

DOI  :  10.5897/JMPR10.453

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Curcuma xanthorrhizais widely used in Indonesia folk medicine to treat liver disorders. This study has evaluated the hepatoprotective activity of standardized ethanolic extract ofC. xanthorrhiza.The extract was standardized using GC-MS. The hepatoprotective activity of this extract was studied using ethanol- induced liver toxicity in rats. This respective activity was assessed through monitoring liver function tests through the measurement of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and protein content. Further, hepatic tissues were also subjected to histopathological studies. Pretreatment of the standardizedC. xanthorrhizaethanolic extract (500 mg/kg) reduced the fatty liver symptoms and significantly (p < 0.05) inhibit the increase of respective serum enzyme levels. The results of the present study indicated thatC. xanthorrhizapossess hepatoprotective effects which could act as an effective treatment for acute hepatic diseases.

【 授权许可】

Unknown