Antioxidant and toxicity activities of Artocarpus lakoocha Roxb. heartwood extract

Dynamic Chiropractic

Supawatchara Singhatong¹  Donrawee Leelarungrayub² 

[1] Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.;Oxidative Stress and Exercise Biochemistry Laboratory, Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.

关键词: Artocarpus lakoocha;    antioxidant;    polyphenolic;    glutathione;    malondialdehyde.;   

DOI  :  10.5897/JMPR10.133

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

The antioxidant activity ofArtocarpus lakoochaheartwood extract was investigated from ethanol extraction by2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid)(ABTS) decolorization, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and H2O2scavenging assay. Polyphenolic; total phenolic, flavonoids and tannins were measured. Anti-oxidative stress was studied in AAPH-oxidized blood and glutathione (GSH), and malondialdehyde (MDA) was evaluated. Results showed that antioxidant activities were 128.30 ± 0.13, 55.86 ± 0.01, and 463.49 ± 0.01 µmol Trolox/g extracted from ABTS, DPPH, and H2O2scavenging methods. One gram of extract contained total phenol (325.63 ± 2.99 mg GE), flavonoids (521.98 ± 0.01 mg QE) and tannins (124.03 ± 0.46 g TE), including rutin and resocinol. In the blood system, a low concentration of extract inhibited MDA progression and improved GSH, which was in contrast to a high concentration with its toxicity effect.

【 授权许可】

Unknown