Characteristics predicting outcomes of allogeneic stem-cell transplantation in relapsed acute myelogenous leukemia

Current oncology

S. Doucette¹  J. Frazer²  S. Couban²  S. Shivakumar³ 

[1] QEII Health Sciences Centre;Dalhousie University;QEII Health Sciences Centre

关键词: Acute myelogenous leukemia;    allogeneic hematopoietic stem-cell transplantation;    hematology;   

DOI  :  10.3747/co.24.3485

学科分类：肿瘤学

来源: Multimed, Inc.

【 摘 要 】

BackgroundAllogeneic hematopoietic stem-cell transplantation (ahsct) is associated with significant morbidity and mortality, but it can cure carefully selected patients with acute myeloid leukemia (aml) in second remission (cr2). In a cohort of patients with aml who underwent ahsct in cr2, we determined the pre-transplant factors that predicted for overall survival (os), relapse, and non-relapse mortality. We also sought to validate the prognostic risk groups derived by Michelis and colleagues in this independent population. MethodsIn a retrospective chart review, we obtained data for 55 consecutive patients who underwent ahsct for aml in cr2. Hazard ratios were used to describe the independent effects of pre-transplant variables on outcome, and Kaplan–Meier curves were used to assess outcomes in the three prognostic groups identified by Michelis and colleagues. ResultsAt 1, 3, and 5 years post-transplant, os was 60%, 45.5%, and 37.5% respectively. Statistically significant differences in os, relapse mortality, and non-relapse mortality were not identified between the prognostic risk groups identified by Michelis and colleagues. Women were less likely than men to relapse, and a modified European Society for Blood and Marrow Transplantation (mebmt) score of 3 or less was associated with a lower non-relapse mortality. ConclusionsThe 37.5% 5-year os in this cohort suggests that, compared with other options, ahsct offers patients with aml in cr2 a better chance of cure. Our study supports the use of the mebmt score to predict non-relapse mortality in this population.

【 授权许可】

Unknown